Article
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling.
Molecular neurobiology - 1 Dec 2016
Salazar Katterine, Martínez Milka, Ulloa Viviana, Bertinat Romina, Martínez Fernando, Jara Nery, Espinoza Francisca, Bongarzone Ernesto R, Nualart Francisco
Abstract excerpt
Expression of the sodium and ascorbic acid (AA) cotransporter SVCT2 is induced during the period of cellular arborization and synaptic maturation of early postnatal (P1-P5) rat cerebral neurons. The physiological importance of the transporter for neurons is evidenced by the lethality and delayed neuronal differentiation detected in mice with ablation of SVCT2. The mechanism(s) involved in these defects and the...
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