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Article

Type VI adenylyl cyclase regulates neurite extension by binding to Snapin and Snap25.

Molecular and cellular biology - 1 Dec 2011

Wu Chia-Shan, Lin Jiun-Tsai, Chien Chen-Li, Chang Wei-Cheng, Lai Hsing-Lin, Chang Ching-Pang, Chern Yijuang

Abstract excerpt

3'-5'-Cyclic AMP (cAMP) is an important second messenger which regulates neurite outgrowth. We demonstrate here that type VI adenylyl cyclase (AC6), an enzyme which catalyzes cAMP synthesis, regulates neurite outgrowth by direct interaction with a binding protein (Snapin) of Snap25 at the N terminus of AC6 (AC6-N). We first showed that AC6 expression increased during postnatal brain development. In primary...

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Identifiers

PMID: 21986494
DOI: 10.1128/MCB.05593-11
PMCID: PMC3233025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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