Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

doi:10.1158/2159-8290.CD-15-1283

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Article

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer.

Cancer discovery - 1 Feb 2016

Russo Mariangela, Siravegna Giulia, Blaszkowsky Lawrence S, Corti Giorgio, Crisafulli Giovanni, Ahronian Leanne G, Mussolin Benedetta, Kwak Eunice L, Buscarino Michela, Lazzari Luca, Valtorta Emanuele, Truini Mauro, Jessop Nicholas A, Robinson Hayley E, Hong Theodore S, Mino-Kenudson Mari, Di Nicolantonio Federica, Thabet Ashraf, Sartore-Bianchi Andrea, Siena Salvatore, Iafrate A John, Bardelli Alberto, Corcoran Ryan B

Abstract excerpt

UNLABELLED: How genomic heterogeneity associated with acquired resistance to targeted agents affects response to subsequent therapy is unknown. We studied EGFR blockade in colorectal cancer to assess whether tissue and liquid biopsies can be integrated with radiologic imaging to monitor the impact of individual oncogenic alterations on lesion-specific responses. Biopsy of a patient's progressing liver metastasis...

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Identifiers

PMID: 26644315
DOI: 10.1158/2159-8290.CD-15-1283
PMCID: PMC4744519

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KRAS
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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