Article
Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial.
The pharmacogenomics journal - 1 Jan 2017
Ellis K L, Zhou Y, Rodriguez-Murillo L, Beshansky J R, Ainehsazan E, Selker H P, Huggins G S, Cupples L A, Peter I
Abstract excerpt
Glucose-insulin-potassium (GIK) therapy may promote a shift from oxygen-wasteful free fatty acid (FFA) metabolism to glycolysis, potentially reducing myocardial damage during ischemia. Genetic variation associated with FFA response to GIK was investigated in an IMMEDIATE (Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care) sub-study (n=117). In patients with...
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