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Article

Meta-Analysis of Rare Variant Association Tests in Multiethnic Populations.

Genetic epidemiology - 1 Jan 2016

Mensah-Ablorh Akweley, Lindstrom Sara, Haiman Christopher A, Henderson Brian E, Marchand Loic Le, Lee Seunngeun, Stram Daniel O, Eliassen A Heather, Price Alkes, Kraft Peter

Abstract excerpt

Several methods have been proposed to increase power in rare variant association testing by aggregating information from individual rare variants (MAF < 0.005). However, how to best combine rare variants across multiple ethnicities and the relative performance of designs using different ethnic sampling fractions remains unknown. In this study, we compare the performance of several statistical approaches for...

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PMID: 26639010
DOI: 10.1002/gepi.21939
PMCID: PMC4968883

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