Article
A High-Throughput Zebrafish Screening Method for Visual Mutants by Light-Induced Locomotor Response.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Gao Yuan, Chan Rosa H M, Chow Tommy W S, Zhang Liyun, Bonilla Sylvia, Pang Chi-Pui, Zhang Mingzhi, Leung Yuk Fai
Abstract excerpt
Normal and visually-impaired zebrafish larvae have differentiable light-induced locomotor response (LLR), which is composed of visual and non-visual components. It is recently demonstrated that differences in the acute phase of the LLR, also known as the visual motor response (VMR), can be utilized to evaluate new eye drugs. However, most of the previous studies focused on the average LLR activity of a particular...
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