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Article

Noncovalent modulation of pH-dependent reactivity of a Mn-salen cofactor in myoglobin with hydrogen peroxide.

Chemistry (Weinheim an der Bergstrasse, Germany) - 27 Jul 2009

Zhang Jun-Long, Garner Dewain K, Liang Lei, Barrios David A, Lu Yi

Abstract excerpt

To demonstrate protein modulation of metal-cofactor reactivity through noncovalent interactions, pH-dependent sulfoxidation and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) oxidation reactivity of a designed myoglobin (Mb) containing non-native Mn-salen complex (1) was investigated using H2O2 as the oxidant. Incorporation of 1 inside the Mb resulted in an increase in the turnover numbers through...

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Identifiers

PMID: 19557774
DOI: 10.1002/chem.200802449
PMCID: PMC2777979

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Source receipt: pubmed, retrieved 7 Sept 2026.

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