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Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

15 Aug 2014

Abstract excerpt

BACKGROUND: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as...

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PMID: 25127496
DOI: 10.1289/ehp.1408418

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