Association of ZEB1 and TCF4 rs613872 changes with late onset Fuchs endothelial corneal dystrophy in patients from northern India.

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Association of ZEB1 and TCF4 rs613872 changes with late onset Fuchs endothelial corneal dystrophy in patients from northern India.

Molecular vision - 1 Jan 2015

Gupta Ranjan, Kumawat Babu Lal, Paliwal Preeti, Tandon Radhika, Sharma Namrata, Sen Seema, Kashyap Seema, Nag Tapas Chandra, Vajpayee Rasik B, Sharma Arundhati

Abstract excerpt

PURPOSE: Fuchs endothelial corneal dystrophy (FECD) results in loss of vision associated with progressive corneal edema and loss of corneal transparency. The aim of the study was to evaluate changes in ZEB1, COL8A2, SLC4A11, and TCF4 rs613872 and correlate them with clinical findings. METHODS: Eighty-two patients with clinically diagnosed FECD and 143 controls were recruited during the period 2007-2012. Clinical...

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PMID: 26622166
PMCID: PMC4638277

Genes

TCF4
ZEB1

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