Article
Diabetes in the post-GWAS era.
Nature genetics - 1 Dec 2015
Polychronakos Constantin, Alriyami Maha
Abstract excerpt
Large sample sizes, high-resolution arrays and comprehensive imputation are pushing genetic fine-mapping of complex trait loci to its limits without, in most cases, pinpointing a unique variant-gene combination. Superimposing these results on sophisticated maps of functional chromatin elements promises to break this logjam, as a new study of type 2 diabetes compellingly demonstrates.
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