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Article

Microenvironmental hypoxia regulates FLT3 expression and biology in AML.

Scientific reports - 30 Nov 2015

Sironi Silvia, Wagner Michaela, Kuett Alexander, Drolle Heidrun, Polzer Harald, Spiekermann Karsten, Rieger Christina, Fiegl Michael

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase constitutively expressed by acute myeloid leukaemia (AML) blasts. In addition, 25% of AML patients harbour a FLT3-ITD mutation, associated with inferior outcome due to increased relapse rate. Relapse might be propagated by interactions between AML blasts and the bone marrow microenvironment. Besides cellular elements of the microenvironment (e.g....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26617391
DOI: 10.1038/srep17550
PMCID: PMC4663471

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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