Article
Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.
European archives of psychiatry and clinical neuroscience - 1 Dec 2016
Isaksson Johan, Grigorenko Elena L, Oreland Lars, Af Klinteberg Britt, Koposov Roman A, Ruchkin Vladislav
Abstract excerpt
Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset...
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