Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Advances in discovering small molecules to probe protein function in a systems context.

Current opinion in chemical biology - 1 Feb 2016

Doyle Shelby K, Pop Marius S, Evans Helen L, Koehler Angela N

Abstract excerpt

High throughput screening (HTS) has historically been used for drug discovery almost exclusively by the pharmaceutical industry. Due to a significant decrease in costs associated with establishing a high throughput facility and an exponential interest in discovering probes of development and disease associated biomolecules, HTS core facilities have become an integral part of most academic and non-profit research...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Discovery
Share to Molecular Probes
Share to Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteins

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 26615565
DOI: 10.1016/j.cbpa.2015.10.032
PMCID: PMC4731259

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Advances in discovering small molecules to probe protein function in a systems context.PMID 26615565Read ↗

Innovation in academic chemical screening: filling the gaps in chemical biology.Semantic proximity Read ↗

From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological Systems.Semantic proximity Read ↗

Design of phenotypic screens for bioactive chemicals and identification of their targets by genetic and proteomic approaches.Semantic proximity Read ↗

Enzyme inhibitor discovery by activity-based protein profiling.Semantic proximity Read ↗

Target identification and mechanism of action in chemical biology and drug discovery.Semantic proximity Read ↗

Protein reporter bioassay systems for the phenotypic screening of candidate drugs: a mouse platform for anti-aging drug screening.Semantic proximity Read ↗

The Emory Chemical Biology Discovery Center: leveraging academic innovation to advance novel targets through HTS and beyond.Semantic proximity Read ↗

Complex phenotypic assays in high-throughput screening.Semantic proximity Read ↗

Chemoproteomic-enabled phenotypic screening.Semantic proximity Read ↗

Target Discovery Driven by Chemical Biology and Computational BiologySemantic proximity Read ↗

An in vivo platform for identifying inhibitors of protein aggregationSemantic proximity Read ↗

Understanding, inhibiting, and engineering membrane transporters with high-throughput mutational screens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.