Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence.

Human pathology - 1 Feb 2016

Pust Alexandra, Kylies Dominik, Hube-Magg Claudia, Kluth Martina, Minner Sarah, Koop Christina, Grob Tobias, Graefen Markus, Salomon Georg, Tsourlakis Maria Christina, Izbicki Jakob, Wittmer Corinna, Huland Hartwig, Simon Ronald, Wilczak Waldemar, Sauter Guido, Steurer Stefan, Krech Till, Schlomm Thorsten, Melling Nathaniel

Abstract excerpt

Aquaporin 5 (AQP5) is an androgen-regulated member of a family of small hydrophobic integral transmembrane water channel proteins regulating cellular water homeostasis and growth signaling. To evaluate its clinical impact and relationship with key genomic alterations in prostate cancer, AQP5 expression was analyzed by immunohistochemistry on a tissue microarray containing 12427 prostate cancers. The analysis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kaplan-Meier Estimate
Share to Neoplasm Grading

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to Oncogene Proteins, Fusion

Share to Prostate-Specific Antigen

Share to PTEN Phosphohydrolase

Share to Tissue Array Analysis

Share to Transcriptional Regulator ERG

Source

Identifiers

PMID: 26614400
DOI: 10.1016/j.humpath.2015.09.026

Genes

AQP5
ERG
PTEN
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence.PMID 26614400Read ↗

Impact of GAS5 genetic polymorphism on prostate cancer susceptibility and clinicopathologic characteristics.Semantic proximity Read ↗

Genetic association analysis identifies a role for ANO5 in prostate cancer progression.Semantic proximity Read ↗

MOLECULAR GENETIC PROFILING OF GLEASON GRADE 4/5 PROSTATE CANCERS COMPARED TO BENIGN PROSTATIC HYPERPLASIASemantic proximity Read ↗

Prevalence of TMPRSS2–ERG and SLC45A3–ERG gene fusions in a large prostatectomy cohortSemantic proximity Read ↗

Ectopic expression of aquaporin-5 in noncancerous epithelial MDCK cells changes cellular morphology and actin fiber formation without inducing epithelial-to-mesenchymal transition.Semantic proximity Read ↗

Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with <i>SLC45A3‐ERG</i> gene rearrangement and an unfavorable clinical courseSemantic proximity Read ↗

SPINK1 expression is tightly linked to 6q15- and 5q21-deleted ERG-fusion negative prostate cancers but unrelated to PSA recurrenceSemantic proximity Read ↗

PTEN losses exhibit heterogeneity in multifocal prostatic adenocarcinoma and are associated with higher Gleason grade.Semantic proximity Read ↗

Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cellsSemantic proximity Read ↗

Down‐regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissuesSemantic proximity Read ↗

Role of human aquaporin 5 in colorectal carcinogenesis.Semantic proximity Read ↗

Reduced KLK2 expression is a strong and independent predictor of poor prognosis in ERG-negative prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.