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Article

TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor.

Human molecular genetics - 1 Feb 2016

Mohagheghi Fatemeh, Prudencio Mercedes, Stuani Cristiana, Cook Casey, Jansen-West Karen, Dickson Dennis W, Petrucelli Leonard, Buratti Emanuele

Abstract excerpt

The aggregation and mislocalization of RNA-binding proteins leads to the aberrant regulation of RNA metabolism and is a key feature of many neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. However, the pathological consequences of abnormal deposition of TDP-43 and other RNA-binding proteins remain unclear, as the specific molecular events that drive...

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Source

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Identifiers

PMID: 26614389
DOI: 10.1093/hmg/ddv491
PMCID: PMC4731020

Genes

SORT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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