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Article

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.

Acta biomaterialia - 1 Feb 2016

Dearth Christopher L, Slivka Peter F, Stewart Scott A, Keane Timothy J, Tay Justin K, Londono Ricardo, Goh Qingnian, Pizza Francis X, Badylak Stephen F

Abstract excerpt

Extracellular matrix (ECM) has been used as a biologic scaffold material to both reinforce the surgical repair of soft tissue and serve as an inductive template to promote a constructive tissue remodeling response. Success of such an approach is dependent on macrophage-mediated degradation and remodeling of the biologic scaffold. Macrophage phenotype during these processes is a predictive factor of the eventual...

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Identifiers

PMID: 26612417
DOI: 10.1016/j.actbio.2015.11.043
PMCID: PMC4728713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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