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Article

Changes in macrophage phenotype and induction of epithelial-to-mesenchymal transition genes following acute Achilles tenotomy and repair.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 2014

Sugg Kristoffer B, Lubardic Jovan, Gumucio Jonathan P, Mendias Christopher L

Abstract excerpt

Tendon injuries occur frequently in physically active individuals, but the clinical outcomes for these injuries can be poor. In many injured tissues the repair process is orchestrated by two types of cells, macrophages and fibroblasts. Macrophages, which have both pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, can directly participate in tissue remodeling and direct the response of other cells...

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Identifiers

PMID: 24700411
DOI: 10.1002/jor.22624
PMCID: PMC4086481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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