Article
Association of Single-Nucleotide Polymorphism in ANK1 with Late-Onset Alzheimer's Disease in Han Chinese.
Molecular neurobiology - 1 Nov 2016
Chi Song, Song Jing-Hui, Tan Meng-Shan, Zhang Wei, Wang Zi-Xuan, Jiang Teng, Tan Lan, Yu Jin-Tai
Abstract excerpt
Recently, two CpG sites in ankyrin 1 (ANK1) gene were identified to be hypermethylated and associated with Alzheimer's disease (AD)-related neuropathology in two large independent studies. Genetic variations are indicated to be involved in DNA methylation, especially when the associated single-nucleotide polymorphisms (SNPs) are located adjacent to the CpG site. Accordingly, ANK1 polymorphisms might contribute to...
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