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Article

Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.

Scientific reports - 27 Nov 2015

Baskin Rebekah, Woods Nicholas T, Mendoza-Fandiño Gustavo, Forsyth Peter, Egan Kathleen M, Monteiro Alvaro N A

Abstract excerpt

Glioma is the most common malignant primary brain tumor and is associated with poor prognosis. Genetic factors contributing to glioma risk have recently been investigated through genome-wide association studies (GWAS), implicating seven independent glioma risk loci in six chromosomal regions. Here, we performed an in-depth functional analysis of the risk locus proximal to the PHLDB1 gene on 11q23.3. We retrieved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

Share to DEAD-box RNA Helicases

Share to Enhancer Elements, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 26610392
DOI: 10.1038/srep17367
PMCID: PMC4661592

Genes

DDX6
PHLDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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