Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific<i>gyrA</i>gene mutations predict poor treatment outcome in MDR-TB

24 Nov 2015

Abstract excerpt

OBJECTIVES: Mutations in the gyrase genes cause fluoroquinolone resistance in Mycobacterium tuberculosis. However, the predictive value of these markers for clinical outcomes in patients with MDR-TB is unknown to date. The objective of this study was to determine molecular markers and breakpoints predicting second-line treatment outcomes in M. tuberculosis patients treated with fourth-generation fluoroquinolones....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Infectious Diseases and Tuberculosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26604243
DOI: 10.1093/jac/dkv360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific<i>gyrA</i>gene mutations predict poor treatment outcome in MDR-TBPMID 26604243Read ↗

Sequence Analysis of Fluoroquinolone Resistance-Associated Genes <i>gyrA</i> and <i>gyrB</i> in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug-Resistant Tuberculosis in New Delhi, IndiaSemantic proximity Read ↗

Association of <i>gyrA/B</i> mutations and resistance levels to fluoroquinolones in clinical isolates of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Usefulness of resistant gene markers for predicting treatment outcome on second-line anti-tuberculosis drugs.Semantic proximity Read ↗

Clinical implications of high-risk mutations in drug resistant tuberculosis (DR-TB): An observational cohort study.Semantic proximity Read ↗

Emergence of Specific gyrA Mutations Associated High-Level Fluoroquinolone-Resistant Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Cases in North India.Semantic proximity Read ↗

Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patients.Semantic proximity Read ↗

Fluoroquinolone resistance and mutational profile of gyrA in pulmonary MDR tuberculosis patientsSemantic proximity Read ↗

Novel multiplex allele-specific PCR assays for the detection of resistance to second-line drugs in Mycobacterium tuberculosis.Semantic proximity Read ↗

gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis.Semantic proximity Read ↗

Mutations in gyrA and gyrB among Fluoroquinolone- and Multidrug-Resistant Mycobacterium tuberculosis Isolates.Semantic proximity Read ↗

Genotypic detection of fluoroquinolone resistance in drug-resistant Mycobacterium tuberculosis at a tertiary care centre in south Coastal Karnataka, India.Semantic proximity Read ↗

Molecular detection of fluoroquinolone resistance-associated gyrA mutations in ofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Iran and Belarus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.