Article
Usefulness of resistant gene markers for predicting treatment outcome on second-line anti-tuberculosis drugs.
Journal of applied microbiology - 1 Dec 2010
Leung K L, Yip C W, Yeung Y L, Wong K L, Chan W Y, Chan M Y, Kam K M
Abstract excerpt
AIM: Mutations in rrs [nucleotide (nt) 1401], gyrA gene (codons 90, 91 or 94), tlyA, ethA and thyA genes of Mycobacterium tuberculosis (MTB) were evaluated for their usefulness in predicting treatment outcome of kanamycin (KM), capreomycin (CPM), ofloxacin (OFX), ethionamide (ETH) and para-aminosalicylic acid (PAS). METHODS AND RESULTS: DNA sequence analyses of these genes were performed against 188 MTB isolates...
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