Article
Molecular detection of fluoroquinolone resistance-associated gyrA mutations in ofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Iran and Belarus.
International journal of mycobacteriology - 1 Sept 2016
Arjomandzadegan Mohammad, Titov Leonid, Farnia Parissa, Owlia Parviz, Ranjbar Reza, Sheikholeslami Fatemeh, Surkova Larissa
Abstract excerpt
OBJECTIVE/BACKGROUND: Detection of mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene could determine resistance to fluoroquinolone antituberculosis drugs. The aim of this study was to detect mutations in QRDRs. METHODS: From 184 clinical isolates of Mycobacterium tuberculosis, ofloxacin resistance was proven in 42 isolates using the proportion method. The molecular basis of...
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