Article
Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy.
Blood - 19 Sept 2013
Jodele Sonata, Licht Christoph, Goebel Jens, Dixon Bradley P, Zhang Kejian, Sivakumaran Theru A, Davies Stella M, Pluthero Fred G, Lu Lily, Laskin Benjamin L
Abstract excerpt
Hematopoietic stem cell transplant (HSCT)-associated thrombotic microangiopathy (TMA) is a complication that occurs in 25% to 35% of HSCT recipients and shares histomorphologic similarities with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). The hallmark of all thrombotic microangiopathies is vascular endothelial cell injury of various origins, resulting in microangiopathic...
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