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An Insight into Recombination with Enterovirus Species C and Nucleotide G-480 Reversion from the Viewpoint of Neurovirulence of Vaccine-Derived Polioviruses.

Scientific reports - 25 Nov 2015

Zhang Yong, Yan Dongmei, Zhu Shuangli, Nishimura Yorihiro, Ye Xufang, Wang Dongyan, Jorba Jaume, Zhu Hui, An Hongqiu, Shimizu Hiroyuki, Kew Olen, Xu Wenbo

Abstract excerpt

A poliomyelitis outbreak caused by type 1 circulating vaccine-derived polioviruses (cVDPVs) was identified in China in 2004. Six independent cVDPVs (eight isolates) could be grouped into a single cluster with pathways of divergence different from a single cVDPV progenitor, which circulated and evolved into both a highly neurovirulent lineage and a less neurovirulent lineage. They were as neurovirulent as the wild...

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Identifiers

PMID: 26603565
DOI: 10.1038/srep17291
PMCID: PMC4658552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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