Article
Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children.
The Journal of infectious diseases - 1 May 2012
Joffret Marie-Line, Jégouic Sophie, Bessaud Maël, Balanant Jean, Tran Coralie, Caro Valerie, Holmblat Barbara, Razafindratsimandresy Richter, Reynes Jean-Marc, Rakoto-Andrianarivelo Mala, Delpeyroux Francis
Abstract excerpt
BACKGROUND: Five cases of poliomyelitis due to type 2 or 3 recombinant vaccine-derived polioviruses (VDPVs) were reported in the Toliara province of Madagascar in 2005. METHODS: We sequenced the genome of the VDPVs isolated from the patients and from 12 healthy children and characterized phenotypic aspects, including pathogenicity, in mice transgenic for the poliovirus receptor. RESULTS: We identified 6 highly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
