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Article

Impact of Exogenous Sequences on the Characteristics of an Epidemic Type 2 Recombinant Vaccine-Derived Poliovirus

26 Jun 2008

Abstract excerpt

Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its...

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PMID: 18579607
DOI: 10.1128/jvi.00239-08

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