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Article

Alteration Analysis of Bone Marrow Mesenchymal Stromal Cells from De Novo Acute Myeloid Leukemia Patients at Diagnosis.

Stem cells and development - 15 May 2017

Desbourdes Laura, Javary Joaquim, Charbonnier Thomas, Ishac Nicole, Bourgeais Jerome, Iltis Aurore, Chomel Jean-Claude, Turhan Ali, Guilloton Fabien, Tarte Karin, Demattei Marie-Veronique, Ducrocq Elfi, Rouleux-Bonnin Florence, Gyan Emmanuel, Hérault Olivier, Domenech Jorge

Abstract excerpt

Bone marrow (BM)-derived mesenchymal stromal cells (MSCs) frequently display alterations in several hematologic disorders, such as acute lymphoid leukemia, acute myeloid leukemia (AML), and myelodysplastic syndromes. In acute leukemias, it is not clear whether MSC alterations contribute to the development of the malignant clone or whether they are simply the effect of tumor expansion on the microenvironment. We...

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Source

Identifiers

PMID: 28394200
DOI: 10.1089/scd.2016.0295

Genes

ANGPT1
MSC
THPO
BMI1
CXCL12
DICER1
JAG1
KITLG
VCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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