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<i>Plasmodium</i> evasion of mosquito immunity and global malaria transmission: The lock-and-key theory

23 Nov 2015

Abstract excerpt

Plasmodium falciparum malaria originated in Africa and became global as humans migrated to other continents. During this journey, parasites encountered new mosquito species, some of them evolutionarily distant from African vectors. We have previously shown that the Pfs47 protein allows the parasite to evade the mosquito immune system of Anopheles gambiae mosquitoes. Here, we investigated the role of...

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PMID: 26598665
DOI: 10.1073/pnas.1520426112

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