Plasmodium falciparum evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor

Abstract excerpt

Significance The surface protein Pfs47 makes Plasmodium falciparum parasites “undetectable” to the mosquito immune system. We proposed the “lock and key” model in which a parasite expressing a compatible Pfs47 haplotype “the key,” is able to evade the mosquito immune system, by interacting with a mosquito Pfs47 receptor “the lock,” which differs between vectors from different continents. Here, we uncovered the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Invertebrate Immune Response Mechanisms
• Share to Malaria Research and Control
• Share to Mosquito-borne diseases and control