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Article

The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action.

Infection and immunity - 1 Feb 2016

Chaili Siyang, Cheung Ambrose L, Bayer Arnold S, Xiong Yan Q, Waring Alan J, Memmi Guido, Donegan Niles, Yang Soo-Jin, Yeaman Michael R

Abstract excerpt

Staphylococcus aureus uses the two-component regulatory system GraRS to sense and respond to host defense peptides (HDPs). However, the mechanistic impact of GraS or its extracellular sensing loop (EL) on HDP resistance is essentially unexplored. Strains with null mutations in the GraS holoprotein (ΔgraS) or its EL (ΔEL) were compared for mechanisms of resistance to HDPs of relevant immune sources: neutrophil...

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Identifiers

PMID: 26597988
DOI: 10.1128/IAI.01030-15
PMCID: PMC4730570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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