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Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

Gastroenterology - 1 Feb 2016

Matzke-Ogi Alexandra, Jannasch Katharina, Shatirishvili Marine, Fuchs Beatrix, Chiblak Sara, Morton Jennifer, Tawk Bouchra, Lindner Thomas, Sansom Owen, Alves Frauke, Warth Arne, Schwager Christian, Mier Walter, Kleeff Jörg, Ponta Helmut, Abdollahi Amir, Orian-Rousseau Véronique

Abstract excerpt

BACKGROUND & AIMS: Cancer cells with high metastatic potential and stem cell-like characteristics express the cell surface marker CD44. CD44 isoforms that include the v6 exon are co-receptors for the receptor tyrosine kinases MET and Vascular Endothelial Growth factor Receptor-2 (VEGFR-2). We studied CD44v6 signaling in several pancreatic cancer cell lines, and its role in tumor growth and metastasis in several...

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PMID: 26597578
DOI: 10.1053/j.gastro.2015.10.020

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MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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