Article
High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition.
Nucleic acids research - 4 Jun 2020
Ou Arnold, Schmidberger Jason W, Wilson Katie A, Evans Cameron W, Hargreaves Jessica A, Grigg Melanie, O'Mara Megan L, Iyer K Swaminathan, Bond Charles S, Smith Nicole M
Abstract excerpt
Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for drug therapy. The nuclease hypersensitive element of the KRAS promoter has been reported to form secondary DNA structures called G-quadruplexes (G4s) which may play important roles in regulating KRAS expression, and has spurred interest in structural elucidation studies of the KRAS G-quadruplexes. Here, we report the first...
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