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Article

Naturally occurring mutations in the thyroglobulin gene.

Thyroid : official journal of the American Thyroid Association - 1 Sept 2005

Vono-Toniolo Jussara, Rivolta Carina M, Targovnik Héctor M, Medeiros-Neto Geraldo, Kopp Peter

Abstract excerpt

Thyroglobulin (Tg) is a large glycoprotein dimer secreted into the follicular lumen. It serves as the matrix for the synthesis of thyroxine (T4) and triiodothyronine (T3), and the storage of thyroid hormone and iodide. In response to demand for thyroid hormone secretion, Tg is internalized into the follicular cell and digested in lysosomes. Subsequently, the thyronines T4 (approximately 80%) and T3 (approximately...

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PMID: 16187910
DOI: 10.1089/thy.2005.15.1021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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