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Article

The acetylcholinesterase homology region is essential for normal conformational maturation and secretion of thyroglobulin.

The Journal of biological chemistry - 23 Apr 2004

Park Young-Nam, Arvan Peter

Abstract excerpt

Secretion of thyroglobulin (Tg, a large homodimeric glycoprotein) is essential to deliver Tg to its site of iodination for thyroxine biosynthesis. An L2263P missense mutation in Tg has been proposed as the molecular defect causing congenital goitrous hypothyroidism in cog/cog mice due to perturbed Tg homodimerization, resulting in its retention within the endoplasmic reticulum. The mutation falls within a...

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Identifiers

PMID: 14764582
DOI: 10.1074/jbc.M314042200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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