Article
Donor-derived stem-cells and epithelial mesenchymal transition in squamous cell carcinoma in transplant recipients.
Oncotarget - 8 Dec 2015
Verneuil Laurence, Leboeuf Christophe, Bousquet Guilhem, Brugiere Charlotte, Elbouchtaoui Morad, Plassa Louis-François, Peraldi Marie-Noelle, Lebbé Celeste, Ratajczak Philippe, Janin Anne
Abstract excerpt
BACKGROUND: Skin squamous-cell-carcinoma (SCC), is the main complication in long-term kidney-transplant recipients, and it can include donor-derived cells. Preclinical models demonstrated the involvement of epithelial mesenchymal transition (EMT) in the progression of skin SCC, and the role of Snail, an EMT transcription factor, in cancer stem-cell survival and expansion.Here, we studied stem-cells and EMT...
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