Article

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase

2020-01-29

Abstract excerpt

<h4>Background: </h4> Down syndrome (DS) is the most common genetic cause of Alzheimer’s Disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved, reliable biomarkers will be required to identify when and how long people with DS should undergo treatment. Three cardinal neuropathological features characterize AD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4d258cf-4217-539a-aaf3-3d4fef69fcad
DOI: 10.21203/rs.2.18106/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increaseDOI 10.21203/rs.2.18106/v2Read

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer’s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) StudySemantic proximity Read

Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patientsSemantic proximity Read

The Alzheimer's Biomarker Consortium‐Down Syndrome: Rationale and methodologySemantic proximity Read

Increased levels of plasma total tau in adult Down syndromeSemantic proximity Read

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndromeSemantic proximity Read

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s diseaseSemantic proximity Read

Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s diseaseSemantic proximity Read

Aging with Down Syndrome—Where Are We Now and Where Are We Going?Semantic proximity Read

Neurofilament light as a blood biomarker for neurodegeneration in Down syndromeSemantic proximity Read

Exploratory analysis of the proteomic profile in plasma in adults with Down syndrome in the context of Alzheimer's diseaseSemantic proximity Read

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read

A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively StableSemantic proximity Read