Geographic EBV variants confound disease-specific variant interpretation and predict variable immune therapy responses.

doi:10.1182/bloodadvances.2023012461

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Article

Geographic EBV variants confound disease-specific variant interpretation and predict variable immune therapy responses.

Blood advances - 23 Jul 2024

Briercheck Edward L, Ravishankar Shashidhar, Ahmed Elshafa Hassan, Carías Alvarado César Camilo, Barrios Menéndez Juan Carlos, Silva Oscar, Solórzano-Ortiz Elizabeth, Siliézar Tala Marcos Mauricio, Stevenson Philip, Xu Yuexin, Wohns Anthony Wilder, Enriquez-Vera Daniel, Barrionuevo Carlos, Yu Shan-Chi, Freud Aharon G, Oakes Christopher, Weigel Christoph, Weinstock David M, Klimaszewski Haley L, Ngankeu Apollinaire, Mutalima Nora, Samayoa-Reyes Gabriela, Newton Robert, Rochford Rosemary, Valvert Fabiola, Natkunam Yasodha, Shustov Andrei, Baiocchi Robert A, Warren Edus H

Abstract excerpt

ABSTRACT: Epstein-Barr virus (EBV) is a potent carcinogen linked to hematologic and solid malignancies and causes significant global morbidity and mortality. Therapy using allogeneic EBV-specific lymphocytes shows promise in certain populations, but the impact of EBV genome variation on these strategies remains unexplored. To address this, we sequenced 217 EBV genomes, including hematologic malignancies from...

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Identifiers

PMID: 38815238
DOI: 10.1182/bloodadvances.2023012461
PMCID: PMC11296253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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