Article
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours.
PLoS genetics - 1 Nov 2015
Arendt Maja L, Melin Malin, Tonomura Noriko, Koltookian Michele, Courtay-Cahen Celine, Flindall Netty, Bass Joyce, Boerkamp Kim, Megquir Katherine, Youell Lisa, Murphy Sue, McCarthy Colleen, London Cheryl, Rutteman Gerard R, Starkey Mike, Lindblad-Toh Kerstin
Abstract excerpt
Canine mast cell tumours (CMCT) are one of the most common skin tumours in dogs with a major impact on canine health. Certain breeds have a higher risk of developing mast cell tumours, suggesting that underlying predisposing germ-line genetic factors play a role in the development of this disease. The genetic risk factors are largely unknown, although somatic mutations in the oncogene C-KIT have been detected in...
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