Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4

17 Nov 2015

Abstract excerpt

Facioscapulohumeral muscular dystrophy is caused by incomplete epigenetic repression of the transcription factor DUX4 in skeletal muscle. A copy of DUX4 is located within each unit of the D4Z4 macrosatellite repeat array and its derepression in somatic cells is caused by either repeat array contraction (FSHD1) or by mutations in the chromatin repressor SMCHD1 (FSHD2). While DUX4 expression has thus far only been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics and Chromatin Dynamics
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26575099
DOI: 10.1080/15592294.2015.1113798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4PMID 26575099Read ↗

Genetic and epigenetic characteristics of FSHD-associated 4q and 10q D4Z4 that are distinct from non-4q/10q D4Z4 homologs.Semantic proximity Read ↗

Loss of epigenetic silencing of the DUX4 transcription factor gene in facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cellsSemantic proximity Read ↗

Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures.Semantic proximity Read ↗

SMCHD1 activates the expression of genes required for the expansion of human myoblastsSemantic proximity Read ↗

SMCHD1 loss triggers DUX4 expression by disrupting splicing in FSHD2Semantic proximity Read ↗

Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2.Semantic proximity Read ↗

Lrif1 modulates Trim28-mediated repression of the <i>Dux</i> locus in mouse embryonic stem cellsSemantic proximity Read ↗

Facioscapulohumeral muscular dystrophy: molecular pathological advances and future directions.Semantic proximity Read ↗

Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei.Semantic proximity Read ↗

Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy.Semantic proximity Read ↗

DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast ProliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.