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Article

Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells

2 Jul 2013

Abstract excerpt

Facioscapulohumeral muscular dystrophy is a dominantly inherited myopathy associated with chromatin relaxation of the D4Z4 macrosatellite array on chromosome 4. DUX4 is encoded within each unit of the D4Z4 array where it is normally transcriptionally silenced and packaged as constitutive heterochromatin. Truncation of the array to less than 11 D4Z4 units (FSHD1) or mutations in SMCHD1 (FSHD2) results in chromatin...

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Identifiers

PMID: 23821646
DOI: 10.1093/hmg/ddt314

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Wnt/β-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cellsPMID 23821646Read ↗

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