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Article

MiR-106b~25 cluster regulates multidrug resistance in an ABC transporter-independent manner via downregulation of EP300.

Oncology reports - 1 Feb 2016

Hu Yunhui, Li Kaiyong, Asaduzzaman Muhammad, Cuella Raquel, Shi Hui, Raguz Selina, Coombes Raoul Charles, Zhou Yuan, Yagüe Ernesto

Abstract excerpt

MicroRNA (miR)-106b~25 cluster regulates bypass of doxorubicin and γ-radiation induced senescence by downregulation of the E-cadherin transcriptional activator EP300. We asked whether upregulation of miR-106~25 cluster generates cells with a truly multidrug resistant (MDR) phenotype and whether this is due to upregulation of the ATP-binding cassette (ABC) transporter P-glycoprotein. We used minimally transformed...

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PMID: 26573761
DOI: 10.3892/or.2015.4412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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