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Article

What Makes Tumors Multidrug Resistant?

15 Nov 2007

Abstract excerpt

Tumors arising "spontaneously" in genetically modified mice now make it possible to study mechanisms of drug resistance in animal tumors resembling their human counterparts. We have studied mouse mammary tumors induced by conditional deletion of Brca1 and p53. These tumors respond to monotherapy with the maximal tolerable dose of doxorubicin, or docetaxel, but eventually always become resistant to the drugs....

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PMID: 17998803
DOI: 10.4161/cc.6.22.4936

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