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Article

The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis in Streptococcus pneumoniae.

Infection and immunity - 1 Feb 2016

Eijkelkamp Bart A, Pederick Victoria G, Plumptre Charles D, Harvey Richard M, Hughes Catherine E, Paton James C, McDevitt Christopher A

Abstract excerpt

Streptococcus pneumoniae is the world's foremost human pathogen. Acquisition of the first row transition metal ion zinc is essential for pneumococcal colonization and disease. Zinc is acquired via the ATP-binding cassette transporter AdcCB and two zinc-binding proteins, AdcA and AdcAII. We have previously shown that AdcAII is reliant upon the polyhistidine triad (Pht) proteins to aid in zinc recruitment. Pht...

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Identifiers

PMID: 26573735
DOI: 10.1128/IAI.01082-15
PMCID: PMC4730578

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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