<scp>AdcA</scp> and <scp>AdcAII</scp> employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in <scp><i>S</i></scp><i>treptococcus pneumoniae</i>

Abstract excerpt

Streptococcus pneumoniae is a globally significant human pathogen responsible for nearly 1 million deaths annually. Central to the ability of S. pneumoniae to colonize and mediate disease in humans is the acquisition of zinc from the host environment. Zinc uptake in S. pneumoniae occurs via the ATP-binding cassette transporter AdcCB, and, unusually, two zinc-binding proteins, AdcA and AdcAII. Studies have...

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