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Article

Identification and Characterization of a Novel Family of Pneumococcal Proteins That Are Protective against Sepsis

1 Feb 2001

Abstract excerpt

Four pneumococcal genes (phtA, phtB, phtD, and phtE) encoding a novel family of homologous proteins (32 to 87% identity) were identified from the Streptococcus pneumoniae genomic sequence. These open reading frames were selected as potential vaccine candidates based upon their possession of hydrophobic leader sequences which presumably target these proteins to the bacterial cell surface. Analysis of the deduced...

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PMID: 11159990
DOI: 10.1128/iai.69.2.949-958.2001

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