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Article

AdcAII of Streptococcus pneumoniae Affects Pneumococcal Invasiveness.

PloS one - 1 Jan 2016

Brown Lindsey R, Gunnell Steven M, Cassella Adam N, Keller Lance E, Scherkenbach Lisa A, Mann Beth, Brown Matthew W, Hill Rebecca, Fitzkee Nicholas C, Rosch Jason W, Tuomanen Elaine I, Thornton Justin A

Abstract excerpt

Across bacterial species, metal binding proteins can serve functions in pathogenesis in addition to regulating metal homeostasis. We have compared and contrasted the activities of zinc (Zn2+)-binding lipoproteins AdcA and AdcAII in the Streptococcus pneumoniae TIGR4 background. Exposure to Zn2+-limiting conditions resulted in delayed growth in a strain lacking AdcAII (ΔAdcAII) when compared to wild type bacteria...

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Identifiers

PMID: 26752283
DOI: 10.1371/journal.pone.0146785
PMCID: PMC4709005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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