Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype.

doi:10.1007/s00213-015-4141-5

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Article

Acute effects of cocaine and cannabis on reversal learning as a function of COMT and DRD2 genotype.

Psychopharmacology - 1 Jan 2016

Spronk Desirée B, Van der Schaaf Marieke E, Cools Roshan, De Bruijn Ellen R A, Franke Barbara, van Wel Janelle H P, Ramaekers Johannes G, Verkes Robbert J

Abstract excerpt

RATIONALE: Long-term cannabis and cocaine use has been associated with impairments in reversal learning. However, how acute cannabis and cocaine administration affect reversal learning in humans is not known. OBJECTIVE: In this study, we aimed to establish the acute effects of administration of cannabis and cocaine on valence-dependent reversal learning as a function of DRD2 Taq1A (rs1800497) and COMT...

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Identifiers

PMID: 26572896
DOI: 10.1007/s00213-015-4141-5
PMCID: PMC4700084

Genes

COMT
DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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