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Article

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

13 Nov 2015

Abstract excerpt

Mitochondrial dysfunction is a key pathophysiological component of many acute and chronic diseases. Maintenance of mitochondrial homeostasis through the balance of mitochondrial turnover, fission and fusion, and generation of new mitochondria via mitochondrial biogenesis is critical for tissue health. Pharmacological activation of mitochondrial biogenesis can enhance oxidative metabolism and tissue bioenergetics,...

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PMID: 26566156
DOI: 10.1146/annurev-pharmtox-010715-103155

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