Article
Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation.
The Journal of biological chemistry - 8 Jan 2016
Yamada Aya, Futagi Masaharu, Fukumoto Emiko, Saito Kan, Yoshizaki Keigo, Ishikawa Masaki, Arakaki Makiko, Hino Ryoko, Sugawara Yu, Ishikawa Momoko, Naruse Masahiro, Miyazaki Kanako, Nakamura Takashi, Fukumoto Satoshi
Abstract excerpt
Cell-cell interaction via the gap junction regulates cell growth and differentiation, leading to formation of organs of appropriate size and quality. To determine the role of connexin43 in salivary gland development, we analyzed its expression in developing submandibular glands (SMGs). Connexin43 (Cx43) was found to be expressed in salivary gland epithelium. In ex vivo organ cultures of SMGs, addition of the gap...
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