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Article

FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis.

BMC developmental biology - 22 Jun 2005

Jaskoll Tina, Abichaker George, Witcher Daniel, Sala Frederic G, Bellusci Saverio, Hajihosseini Mohammad K, Melnick Michael

Abstract excerpt

BACKGROUND: Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during embryonic SMG development. To address this question, we have analyzed the SMG phenotype in Fgf10 and Fgfr2b heterozygous and null mutant mice. In addition, although previous studies suggest that the FGF10/FGFR2b and FGF8/FGFR2c signaling pathways are...

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Share to Cell Proliferation
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Fibroblast Growth Factor 10

Share to Fibroblast Growth Factor 8

Share to Mice, Knockout

Share to Morphogenesis

Share to Receptor, Fibroblast Growth Factor, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 15972105
DOI: 10.1186/1471-213X-5-11
PMCID: PMC1184065

Genes

FGF10
FGF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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